CAMPTOTHECIN AND KHAT (CATHA EDULIS FORSK.) INDUCED DISTINCT CELL DEATH PHENOTYPES INVOLVING MODULATION OF C-FLIPL, MCL-1, PROCASPASE-8 AND MITOCHONDRIAL FUNCTION IN ACUTE MYELOID LEUKEMIA CELL LINES

Abstract Background An organic extract of the recreational herb khat (Catha edulis Forsk.) triggers cell death in various leukemia cell lines in vitro.The chemotherapeutics camptothecin, a plant alkaloid topoisomerase I inhibitor, was tested side-by-side with khat in a panel of acute myeloid leukemia cell mel axolotl lines to elucidate mechanisms o

Human observers are remarkably proficient at recognizing expressions of emotions and at readily grouping them into distinct categories.When morphing one facial expression into another, the linear changes in low-level features are insufficient to describe the changes in perception, which instead follow an s-shaped function.Important questions are, w

Field work research on population dynamic of snails from the regions of Belo Horizonte and Lagoa Santa give much information about interactions among two or more species of mollusks: Pomacea haustrum, Biomphalaria glabrata, B.tenagophila, B.straminea and Melanoides tuberculata.Data ranging from two years to several decades ago suggest that the Pamp

Objectives This study aims to understand the breadth of practice around end-of-life withdrawal of non-invasive advanced respiratory support (encompassing both continuous positive airway pressure and non-invasive ventilation) by analysing NHS-published guidelines and guidance for clinicians.This study seeks validity in the guidelines through a confl